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富含GC啟動子結(jié)合蛋白1/血管壁相連蛋白抗體
  • 產(chǎn)品貨號：
    BN40426R
  • 中文名稱：
    富含GC啟動子結(jié)合蛋白1/血管壁相連蛋白抗體
  • 英文名稱：
    Rabbit anti-GPBP1 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN40426R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Mouse(predicted:Human,Rat,Chicken,Dog,Pig,Cow,Horse,Sheep) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN40426R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Mouse(predicted:Human,Rat,Chicken,Dog,Pig,Cow,Horse,Sheep) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱GPBP1
中文名稱富含GC啟動子結(jié)合蛋白1/血管壁相連蛋白抗體
別    名Vasculin; DKFZp761C169; GC rich promoter binding protein 1; GC-rich promoter-binding protein 1; GPBP; Gpbp1; GPBP1_HUMAN; MGC126339; SSH6; Vascular wall linked; Vascular wall-linked protein.  
研究領(lǐng)域細(xì)胞生物  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse,  (predicted: Human, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量53kDa
細(xì)胞定位細(xì)胞核 細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human GPBP1/Vasculin:11-110/473 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Vascular wall-linked protein, or Vasculin, is primarily expressed in the arterial wall and in plasma. It is also differentially expressed in human atherogenesis. Alternative splicing of exon 3 of the Vasculin gene produces three variants. Vasculin binds to and activates the minimal self-sufficient promoter element (MSPE) of the mouse Ada gene promoter and binds to and partially suppresses the GC-rich promoter of the nonhomologous human TOP2A gene promoter. It acts as a nuclear factor that can form complexes with TATA-binding proteins, transcription factors TFIIB and TFIIF, RNA polymerase II and p300. The regulated expression of Vasculin in plaques suggests that it may be involved in atherogenesis, and its presence in plasma may implicate Vasculin as a marker for atherosclerosis.

Function:
Functions as a GC-rich promoter-specific transactivating transcription factor.

Subunit:
Interacts with GTF2B, GTF2F2, RNA polymerase II and TBP (By similarity).

Subcellular Location:
Nucleus. Cytoplasm. According to PubMed:12842993, it localizes to the cytoplasm.

Tissue Specificity:
Widely expressed. Some isoforms may be specifically expressed in veins and arteries (at protein level). Isoform 4 is widely expressed. Isoform 1, isoform 2 and isoform 3 may be specifically expressed in vascular smooth muscle cells.

Similarity:
Belongs to the vasculin family.

SWISS:
Q86WP2

Gene ID:
65056

Database links:

Entrez Gene: 65056 Human

Entrez Gene: 73274 Mouse

Entrez Gene: 294734 Rat

Entrez Gene: 613751 Cow

SwissProt: Q0P5K1 Cow

SwissProt: Q86WP2 Human

SwissProt: Q9H0D4 Human

SwissProt: Q9H785 Human

SwissProt: Q3TQR2 Mouse

SwissProt: Q6NXH3 Mouse

SwissProt: Q6TYE7 Mouse

SwissProt: Q8R252 Mouse

Unigene: 17440 Cow

Unigene: 444279 Human

Unigene: 441830 Mouse

Unigene: 57286 Mouse

Unigene: 33325 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.