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原腸胚雙向形成相關(guān)蛋白抗體
  • 產(chǎn)品貨號(hào)：
    BN40331R
  • 中文名稱：
    原腸胚雙向形成相關(guān)蛋白抗體
  • 英文名稱：
    Rabbit anti-Chordin Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號(hào)

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  • BN40331R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：nan(predicted:Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用：WB,ELISA

  • BN40331R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：nan(predicted:Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用：WB,ELISA

產(chǎn)品描述

英文名稱Chordin
中文名稱原腸胚雙向形成相關(guān)蛋白抗體
別    名Chordin; Chrd; CHRD_HUMAN; MGC133038; Shortgastrulation protein; SOG.  
研究領(lǐng)域細(xì)胞生物  發(fā)育生物學(xué)  神經(jīng)生物學(xué)  干細(xì)胞  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量99kDa
細(xì)胞定位分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Chordin:412-490/951 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The patterning of the CNS relies on the interaction of multiple signaling molecules such as Sonic Hedgehog, Wnts, and BMPs and their antagonists Chordin and Noggin. At midgastrula, expression of Noggin overlaps that of Chordin. Chordin is a key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The gene which encodeschordin maps to human chromosome 3q27. Noggin is a secreted protein that binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily of signaling proteins, such as BMP-2,4,7. The gene which encodes noggin maps to human chromosome 17q22.

Function:
Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.

Subunit:
Interacts with TWSG1 and/or BMP4

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed at the highest level in liver.

Post-translational modifications:
Cleaved by tolloid proteases; cleavage participates to dorsoventral patterning during early development.

Similarity:
Belongs to the chordin family.
Contains 4 CHRD domains.
Contains 4 VWFC domains.

SWISS:
Q9H2X0

Gene ID:
8646

Database links:

Entrez Gene: 8646 Human

Entrez Gene: 12667 Mouse

Entrez Gene: 117275 Rat

Omim: 603475 Human

SwissProt: Q9H2X0 Human

SwissProt: Q9Z0E2 Mouse

SwissProt: Q63148 Rat

Unigene: 166186 Human

Unigene: 20457 Mouse

Unigene: 29459 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
















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