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輔酶Q10B抗體
  • 產(chǎn)品貨號(hào)：
    BN40322R
  • 中文名稱：
    輔酶Q10B抗體
  • 英文名稱：
    Rabbit anti-COQ10B Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40322R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse(predicted:Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep,Orangutan) 推薦應(yīng)用：WB,ELISA

  • BN40322R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse(predicted:Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep,Orangutan) 推薦應(yīng)用：WB,ELISA

產(chǎn)品描述

英文名稱COQ10B
中文名稱輔酶Q10B抗體
別    名Coenzyme Q10; Coenzyme Q10 B; Coenzyme Q10 homolog B; Coenzyme Q10B; CQ10B_HUMAN.  
研究領(lǐng)域腫瘤  細(xì)胞生物  免疫學(xué)  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  Alzheimer's  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse,  (predicted: Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Orangutan)
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量23kDa
細(xì)胞定位細(xì)胞漿 細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human COQ10B:38-110/238 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹COQ10B, Coenzyme Q10, is a 247 amino acid protein encoded by the human gene COQ10B. COQ10B is a mitochondrial protein that belongs to the COQ10 family. COQ10B is an essential biological cofactor which increases brain mitochondrial concentration and exerts neuroprotective effects. Plasma COQ10B levels decrease in patients with advanced chronic heart failure (CHF) while COQ10B levels in hyperthyroid patients are found among the lowest detected in human diseases. Likewise, COQ10B is elevated in hypothyroid subjects, also in subclinical conditions, suggesting the usefulness of this index in assessing metabolic status in thyroid disorders. It is believed that secretion of adrenal hormones is in some way related to COQ10B levels, both in augmented and reduced conditions. However, since thyroid hormones have an important role in modulating COQ10B levels and metabolism, when coexistent, thyroid deficiency seems to play a prevalent role in comparison with adrenal deficiency.

Function:
COQ10 (Coenzyme Q10) is found in a wide variety of foods and is synthesized in all tissues. The de novo biosynthesis of COQ10, from its precursor tyrosine, is a multistage process that requires at least eight vitamins and several trace elements. More complex enzymes have an absolute dependancy on 'cofactors', a large group of molecules to which the coenzymes belong, for their catalyitic function. Coenzyme Q10 is the cofactor for, but not limited to, several mitochondrial enzymes that are central to the supply of adenosine triphosphate (ATP). In addition, COQ10 in its reduced form is a potent antioxidant, and in this capacity, a reduction in COQ10 levels are associtated with a variety of degenerative process including skin aging and neurodegenerative conditions such as Alzhiemer's, Huntingdon's and Parkinson's diseases.

Subunit:
Interacts with coenzyme Q

Subcellular Location:
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side

Similarity:
Belongs to the COQ10 family.

SWISS:
Q9H8M1

Gene ID:
80219

Database links:

Entrez Gene: 80219 Human

Entrez Gene: 67876 Mouse

SwissProt: Q9H8M1 Human

SwissProt: Q3THF9 Mouse

SwissProt: Q5I0I9 Rat

Unigene: 632547 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.