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跨膜蛋白59抗體
  • 產(chǎn)品貨號：
    BN40321R
  • 中文名稱：
    跨膜蛋白59抗體
  • 英文名稱：
    Rabbit anti-TMEM59 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN40321R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Mouse(predicted:Human,Rat,Dog,Pig,Cow,Rabbit) 推薦應(yīng)用：WB,ELISA

  • BN40321R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Mouse(predicted:Human,Rat,Dog,Pig,Cow,Rabbit) 推薦應(yīng)用：WB,ELISA

產(chǎn)品描述

英文名稱TMEM59
中文名稱跨膜蛋白59抗體
別    名C1orf8; HSPC001; Liver membrane-bound protein; TMEM59; TMEM59 transmembrane protein 59; TMM59_HUMAN; Transmembrane protein 59.  
研究領(lǐng)域細胞生物  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  Alzheimer's  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse,  (predicted: Human, Rat, Dog, Pig, Cow, Rabbit, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量33kDa
細胞定位細胞漿 細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human TMEM59:141-240/323 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹TMEM59 is a 144 amino acid protein encoded by a gene mapping to human chromosome 1. Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma.

Function:
Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding.

Subcellular Location:
Golgi apparatus membrane.

Post-translational modifications:
N-glycosylated.

Similarity:
Belongs to the TMEM59 family.

SWISS:
Q9BXS4

Gene ID:
9528

Database links:

Entrez Gene: 509775 Cow

Entrez Gene: 9528 Human

Entrez Gene: 56374 Mouse

Entrez Gene: 100196907 Rat

SwissProt: Q3T0Q2 Cow

SwissProt: Q9BXS4 Human

SwissProt: Q9QY73 Mouse

Unigene: 726034 Human

Unigene: 291192 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.















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