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阿爾茨海默病淀粉樣蛋白相關膠原蛋白抗體
  • 產品貨號：
    BN40320R
  • 中文名稱：
    阿爾茨海默病淀粉樣蛋白相關膠原蛋白抗體
  • 英文名稱：
    Rabbit anti-CLACP Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產品規(guī)格

    售價

    備注

  • BN40320R-100ul

    100ul

    ￥2360.00

    交叉反應：Mouse,Rat(predicted:Human,Chicken,Dog,Cow,Horse,Sheep) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN40320R-200ul

    200ul

    ￥3490.00

    交叉反應：Mouse,Rat(predicted:Human,Chicken,Dog,Cow,Horse,Sheep) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,ELISA

產品描述

英文名稱CLACP
中文名稱阿爾茨海默病淀粉樣蛋白相關膠原蛋白抗體
別    名Alzheimer disease amyloid associated protein; AMY; CLAC; CLAC P; CLAC precursor; COL25A1; COL25A1 protein; Collagen alpha 1 XXV chain; Collagen alpha 1(XXV) chain; Collagen like Alzheimer amyloid plaque component; Collagen like Alzheimer amyloid plaque component precursor; Collagen type XXV alpha 1; Collagenous Alzheimer amyloid plaque component.  
研究領域神經生物學  Alzheimer's  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Mouse, Rat,  (predicted: Human, Chicken, Dog, Cow, Horse, Sheep, )
產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量65kDa
細胞定位細胞膜 分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human CLACP:581-654/654 <Extracellular>
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹Collagen proteins (products of the COL gene family) are fibrous, extracellular matrix proteins with high tensile strength and are the major components of connective tissue such as tendons and cartilage. All collagens contain a triple helix domain and frequently show lateral self-association in order to form complex connective tissues. The Collagen Type XXV precursor produces the proteolytic fragment CLAC (collagenous Alzheimer amyloid plaque component), which deposits in senile plaques associated with amyloid beta peptides (Abeta) in the brains of patients with Alzheimer's disease. CLAC binds to the fibrillized form of Abeta, which disturbs the structure and function of plasma membranes.

Function:
Antibodies against senile plaque (SP) amyloid obtained a clone 9D2, which labeled amyloid fibrils in SPs and reacted with approximately 50/100 kDa polypeptides in Alzheimer's diseased (AD) brains. The 9D2 antigen was identified as CLAC (collagen like Alzheimer amyloid plaque component), and its precursor as CLACP/collagen type XXV. Both secreted and membrane tethered forms of CLACP/collagen type XXV specifically bound to fibrillized Abeta, implicating these proteins in beta amyloidogenesis and neuronal degeneration in AD.

Subunit:
o assemble amyloid fibrils into protease-resistant aggregates. Binds heparin. [SUBUNIT] Forms homodimers and homotrimers. Binds to the fibrillized forms of beta amyloid peptide 40 (beta-APP40) and beta amyloid peptide 42 (beta-APP42). Found associated with beta-APP42 more frequently than with beta-APP40.

Subcellular Location:
Membrane; Single-pass type II membrane protein (Potential). Note=After proteolytic cleavage, CLAC is secreted.

Tissue Specificity:
Expressed predominantly in brain. Deposited preferentially in primitive or neuritic amyloid plaques which are typical of Alzheimer disease.

Post-translational modifications:
Undergoes proteolytic cleavage by furin protease to yield the soluble collagen-like Alzheimer amyloid plaque component.
Glycosylated.
Hydroxylated on 11% of proline residues and 49% of lysine residues.

Similarity:
Contains 7 collagen-like domains.

SWISS:
Q9BXS0

Gene ID:
84570

Database links:

Entrez Gene: 84570 Human

Entrez Gene: 77018 Mouse

Entrez Gene: 687064 Rat

Omim: 610004 Human

SwissProt: Q9BXS0 Human

SwissProt: Q99MQ5 Mouse

Unigene: 658842 Human

Unigene: 91728 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.