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神經(jīng)腫瘤Nova1抗原抗體
  • 產(chǎn)品貨號(hào)：
    BN40301R
  • 中文名稱：
    神經(jīng)腫瘤Nova1抗原抗體
  • 英文名稱：
    Rabbit anti-Nova1 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40301R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Cow) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN40301R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Cow) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱Nova1
中文名稱神經(jīng)腫瘤Nova1抗原抗體
別    名Neuro oncological ventral antigen 1; Neuro-oncological ventral antigen 1; NOVA 1; Nova-1; Nova1; NOVA1_HUMAN; Onconeural ventral antigen 1; Paraneoplastic Ri antigen; RNA binding protein Nova 1; RNA-binding protein Nova-1; Ventral neuron specific protein 1; Ventral neuron-specific protein 1.  
研究領(lǐng)域腫瘤  細(xì)胞生物  神經(jīng)生物學(xué)  細(xì)胞類型標(biāo)志物  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat,  (predicted: Chicken, Cow, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量52kDa
細(xì)胞定位細(xì)胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Nova1:411-510/510 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Nova-1 and Nova-2 are members of a superfamily of protein regulators of RNA metabolism in neurons. Both are nuclear RNA binding proteins with K homology motifs, conserved protein sequences which bind to RNA (1,2). Nova proteins, normally sequestered in the central nervous system, are expressed by systemic tumors in patients with the autoimmune disorder paraneoplastic opsoclonus-myoclonus ataxia (POMA) (3,4). Nova-1 is expressed in the hindbrain and ventral spinal cord and Nova-2 is expressed in the neocortex and hippocampus (4). Nova-1 is necessary for regulating neuron-specific alternative splicing of the glycine receptor Alpha2 pre-mRNA (5).

Function:
May regulate RNA splicing or metabolism in a specific subset of developing neurons.

Subunit:
Interacts with PTBP2; the interaction is direct (By similarity).

Subcellular Location:
Nucleus.

Tissue Specificity:
Brain.

Similarity:
Contains 3 KH domains.

SWISS:
P51513

Gene ID:
4857

Database links:

Entrez Gene: 4857 Human

Entrez Gene: 664883 Mouse

Entrez Gene: 298992 Rat

Omim: 602157 Human

SwissProt: Q2PFW9 Cynomolgus monkey

SwissProt: P51513 Human

SwissProt: Q9JKN6 Mouse

SwissProt: Q80WA4 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications