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Rho GTP酶激活蛋白26抗體
  • 產(chǎn)品貨號(hào)：
    BN40292R
  • 中文名稱(chēng)：
    Rho GTP酶激活蛋白26抗體
  • 英文名稱(chēng)：
    Rabbit anti-GRAF Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40292R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Rabbit,Sheep) 推薦應(yīng)用：WB,ELISA

  • BN40292R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Rabbit,Sheep) 推薦應(yīng)用：WB,ELISA

產(chǎn)品描述

英文名稱(chēng)GRAF
中文名稱(chēng)Rho GTP酶激活蛋白26抗體
別    名arhgap 26; ARHGAP26; FLJ42530; GRAF; GRAF1; GTPase regulator associated with focal adhesion kinase; GTPase regulator associated with focal adhesion kinase pp125(FAK); KIAA0621; oligophrenin 1 like protein; Oligophrenin-1-like protein; oligophrenin1like protein; OPHN1L; OPHN1L1; RHG26_HUMAN; Rho GTPase activating protein 26; Rho GTPase activating protein26; Rho GTPase-activating protein 26; Rho-type GTPase-activating protein 26.  
研究領(lǐng)域腫瘤  心血管  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞骨架  細(xì)胞外基質(zhì)  G蛋白信號(hào)  
抗體來(lái)源Rabbit
克隆類(lèi)型Polyclonal
交叉反應(yīng)Human, Mouse, Rat,  (predicted: Chicken, Dog, Pig, Cow, Rabbit, Sheep, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量92kDa
細(xì)胞定位細(xì)胞漿 細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human GRAF1:1-100/814 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Cellular signaling by G-proteins is down-regulated by GTPase-activating proteins (GAPs), which increase the rate of GTP hydroylsis. The GTPase regulator associated with focal adhesion kinase (GRAF) has GAP activity toward Rho A and Cdc42, but not Rac1. GRAF is ubiquitously expressed with high levels in heart and brain. Expression of GRAF causes clearing of stress fibers and formation of long actin based filopodial-like extensions. Fusion of MLL with GRAF, MLL/GRAF, is included in a rare genetic subgroup of acute myeloid leukemia (AML) cases.

Function:
GTPase-activating protein for RHOA and CDC42.

Subunit:
Interacts with NYAP1, NYAP2 and MYO16 (By similarity). Binds to the C-terminus of PTK2/FAK1.

Subcellular Location:
Cell junction; focal adhesion. Cytoplasm; cytoskeleton. Colocalizes with actin stress fibers and cortical actin structures.

DISEASE:
Defects in ARHGAP26 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:607785]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. Chromosomal translocation t(5;11)(q31;q23) with MLL has been found in a JMML patient.

Similarity:
Contains 1 PH domain. Contains 1 Rho-GAP domain. Contains 1 SH3 domain.

SWISS:
Q9UNA1

Gene ID:
23092

Database links:

Entrez Gene: 23092 Human

Entrez Gene: 71302 Mouse

Entrez Gene: 307459 Rat

Omim: 605370 Human

SwissProt: Q9UNA1 Human

SwissProt: Q6ZQ82 Mouse

Unigene: 654668 Human

Unigene: 329396 Mouse

Unigene: 214162 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

















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