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RhoB蛋白抗體
  • 產(chǎn)品貨號(hào)：
    BN40286R
  • 中文名稱：
    RhoB蛋白抗體
  • 英文名稱：
    Rabbit anti-Rho B Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40286R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human(predicted:Mouse,Rat,Chicken,Dog,Rabbit) 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,ELISA

  • BN40286R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human(predicted:Mouse,Rat,Chicken,Dog,Rabbit) 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱Rho B
中文名稱RhoB蛋白抗體
別    名Rh -related GTP binding protein RhoB; Rh -related GTP binding protein RhoC; RHOH6; Transforming protein RhoA; AA017882 antibody Aplysia ras related homolog 9 (RhoC); ARH9; ARHA; ARHB; ARHC; H6; MST081; MSTP08; Oncogene RHO H9; rhoC GTPase; Ras homolog 9 (RhoC); Ras homolog gene family, member A; Ras homolog gene family, member B; Ras homolog gene family, member C; Rho related GTP binding protein RhoC; RHO12; RHOB; RHOC; RHOH9; RP11-426L16.4; Small GTP binding protein RhoC; H9; Rho related GTP binding protein RhoB; ARH12; ARH6; H12.RHOB_HUMAN  
研究領(lǐng)域細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  激酶和磷酸酶  
抗體來(lái)源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human,  (predicted: Mouse, Rat, Chicken, Dog, Rabbit, )
產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量22kDa
細(xì)胞定位細(xì)胞核 細(xì)胞漿 細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Rho B:101-196/196 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The Rho proteins interact directly with protein kinases which are likely to serve as downstream effector targets of the activated GTPase. The Rho family of GTPases are involved in the regulation of the actin skeleton. Activation of Rho to the GTP bound state promotes formation of stress fibers and is required for the formation and maintenance of focal adhesions. Pathways stimulated by cytokines, hormones and various forms of stress utilize p21 proteins of the Rho family. Possible mediators for these responses include protein kinase such as p120PKN, and p150 ROKa/Rho-A kinase, myosin light chain (MLC) phosphatase and PIP 5-kinase.

Function:
Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.

Subunit:
Binds ROCK1 and ROCK2. Also binds PKN1/PRK1. Interacts with ARGGEF3, RTKN and AKAP13.

Subcellular Location:
Rho A: Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm; cytoskeleton. Rho B: Late endosome membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Nucleus. Rho C: Cell membrane; Lipid-anchor; Cytoplasmic side.

Post-translational modifications:
Prenylation specifies the subcellular location of RHOB. The farnesylated form is localized to the plasma membrane while the geranylgeranylated form is localized to the endosome.

Similarity:
Belongs to the small GTPase superfamily. Rho family.

SWISS:
P62745

Gene ID:
388

Database links:

Entrez Gene: 395734 Chicken

Entrez Gene: 515118 Cow

Entrez Gene: 388 Human

Entrez Gene: 11852 Mouse

Entrez Gene: 100144503 Pig

Entrez Gene: 64373 Rat

Omim: 165370 Human

SwissProt: Q3ZBW5 Cow

SwissProt: P62745 Human

SwissProt: P62746 Mouse

SwissProt: P62747 Rat

Unigene: 502876 Human

Unigene: 687 Mouse

Unigene: 2042 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.