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環(huán)指蛋白111抗體
  • 產(chǎn)品貨號：
    BN40272R
  • 中文名稱：
    環(huán)指蛋白111抗體
  • 英文名稱：
    Rabbit anti-RNF111 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN40272R-100ul

    100ul

    ￥2360.00

    交叉反應：Mouse,Rat(predicted:Human,Dog,Cow,Rabbit,Sheep) 推薦應用：IHC-P,IHC-F,ICC,IF,ELISA

  • BN40272R-200ul

    200ul

    ￥3490.00

    交叉反應：Mouse,Rat(predicted:Human,Dog,Cow,Rabbit,Sheep) 推薦應用：IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱RNF111
中文名稱環(huán)指蛋白111抗體
別    名ARK; Arkadia; DKFZp313E0731; DKFZp686H1966; DKFZp761D081; E3 ubiquitin protein ligase Arkadia; FLJ38008; Ring finger protein 111; RNF 111; RN111_HUMAN.  
研究領域細胞生物  免疫學  信號轉(zhuǎn)導  生長因子和激素  泛素  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Mouse, Rat,  (predicted: Human, Dog, Cow, Rabbit, Sheep, )
產(chǎn)品應用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量109kDa
細胞定位細胞核 細胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human RNF111:851-950/994 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]

Function:
Acts in the NODAL pathway of mesoderm patterning during embryonic development. Acts downstream AXIN1 as an E3 ubiquitin-protein ligase which promotes the ubiquitination of inhibitory SMADs such as SMAD7, induces their proteasomal degradation and thereby enhances the transcriptional activity of TGF-beta and BMP. Activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation.

Subunit:
Interacts with SMAD6, SMAD7, AXIN1, AXIN2 and SKIL isoform SNON. Part of a complex containing RNF111, AXIN1 and SMAD7. Interacts (via SIM domains) with SUMO1 and SUMO2.

Subcellular Location:
Cytoplasmic and Nuclear

Tissue Specificity:
Broadly expressed.

Similarity:
Contains 1 RING-type zinc finger.

SWISS:
Q6ZNA4

Gene ID:
54778

Database links:

Entrez Gene: 54778 Human

Omim: 605840 Human

SwissProt: Q6ZNA4 Human

Unigene: 404423 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications