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甲狀腺過(guò)氧化物酶抗體
  • 產(chǎn)品貨號(hào)：
    BN40251R
  • 中文名稱：
    甲狀腺過(guò)氧化物酶抗體
  • 英文名稱：
    Rabbit anti-Thyroid peroxidase Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40251R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Rat(predicted:Mouse) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

  • BN40251R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Rat(predicted:Mouse) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱Thyroid peroxidase
中文名稱甲狀腺過(guò)氧化物酶抗體
別    名MSA; PERT_HUMAN; TDH2A; Thyroid microsomal antigen; Thyroid peroxidase; Thyroperoxidase; TPO; TPX.  
抗體來(lái)源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Rat,  (predicted: Mouse, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量101kDa
細(xì)胞定位細(xì)胞膜 細(xì)胞外基質(zhì) 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Thyroid peroxidase:111-210/933 <Extracellular>
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011].

Function:
Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).

Subunit:
Interacts with DUOX1, DUOX2 and CYBA.

Subcellular Location:
Membrane; Single-pass type I membrane protein.
Isoform 3: Cell surface.

Post-translational modifications:
Glycosylated.
Heme is covalently bound through a H(2)O(2)-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface.
Cleaved in its N-terminal part.

DISEASE:
Note=An alternative splicing in the thyroperoxidase mRNA can cause Graves' disease.
Defects in TPO are the cause of thyroid dyshormonogenesis 2A (TDH2A) [MIM:274500]. A disorder due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete.

Similarity:
Belongs to the peroxidase family. XPO subfamily.
Contains 1 EGF-like domain.
Contains 1 Sushi (CCP/SCR) domain.

SWISS:
P07202

Gene ID:
7173

Database links:

Entrez Gene: 7173 Human

Omim: 606765 Human

SwissProt: P07202 Human

Unigene: 467554 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.



















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